Cyclization process for synthesis of a beta-lactam carbapenem in

Details Cyclization process for synthesis of a beta-lactam carbapenem in Cyclization process for synthesis of a beta-lactam carbapenem in

1990-08-14

1991-08-06

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07B 4306

Patent

active

050379747

ABSTRACT:
A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

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T. Kametani et al., J. Am. Chem. Soc., vol. 102, pp. 2060-2065.
L. Birkofer et al., Liebig's Analen Chem., 1975, pp. 2195-2200.
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T. Mukaiyama et al., Tetrahedron Letters, No. 22, pp. 1901-1904.

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