Cyclization process for substituted benzothiazole derivatives

Details Cyclization process for substituted benzothiazole derivatives Cyclization process for substituted benzothiazole derivatives

2006-08-08

2006-08-08

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S164000

Reexamination Certificate

active

07087761

ABSTRACT:
The present invention relates to a process for preparation of amino substituted benzothiazole derivatives of formula IwhereinR1, R2and R3are independently from each other hydrogen, lower alkyl, lower alkoxy or halogen;R4is hydrogen, lower alkyl, lower alkyloxy, halogen,or is a five or six membered non aromatic heterocyclyl group, unsubstituted or substituted by lower alkyl or an oxo-group, or is—NR5R6, wherein R5and R5are independently from each other hydrogen, lower alkyl, —C(O)-lower alkyl, —(CH2)nO-lower alkyl or benzyl, opionally substituted by lower alkyl, or is an five or six membered heteroaryl group;R1and R2or R2and R3may form together with the corresponding carbon atoms a ring containing —O—CH2—O— or —CH═CH—CH═CH—;R is hydrogen or —C(O)R′;R′ is a five or six membered non aromatic heterocyclyl group, five or six membered heteroaryl group or is aryl, which rings may be substituted by the groups, selected from lower alkyl, halogen-lower alkyl, lower alkoxy, cyano, nitro, —C(O)H, —C(O)OH or by pyrrolidin-1-yl-methyl;n is 1 to 4;or a pharmaceutically acceptable salt thereof,wherein the cyclization is carried out by the treatment of a compound of formulawith sulphoxide/HBr/solvent to give the desired products of formula I for R is hydrogen (formula IA) or for R is —C(O)R′ (formula IB)

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