Cyclization process for producing aziridine-2-carboxylic acid or

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D20302, C07D20308

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043930000

ABSTRACT:
A process for producing aziridine-2-carboxylic acid or its salts is provided which comprises treating an alpha-halogeno-beta-aminopropionitrile or its mineral acid salt with an alkali or alkaline earth metal hydroxide in water or in a water-containing organic solvent. In a preferred embodiment, aziridine-2-carboxylic acid or its salt is produced by treating the reaction mixture containing an alpha-halogeno-beta-aminopropionitrile obtained by reacting an alpha, beta-dihalogenopropionitrile or an alpha-halogenoacrylonitrile with ammonia, with an alkali or alkaline earth metal hydroxide in the presence of water without isolating the alpha-halogeno-beta-aminopropionitrile from the reaction mixture beforehand.

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Antonov et al., Z. Obshchei Khim 29, 1132, (1959).
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Gundermann et al., Chem. Ber., vol. 93, pp. 1632-1633 and 1638-1641, (1960).
Kyburz, E., Hev. Chim. Acta, vol. 49, pp. 359 and 368, (1966).

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