Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-05-16
1997-11-18
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548226, 548228, 548233, C07D26304, C07D26316, C07D26346
Patent
active
056889623
ABSTRACT:
A process for the synthesis of a compound of general formula II: ##STR1## wherein: R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl;
A is an aromatic or heteroaromatic ring system optionally substituted with one or more substituents as defined herein; and in which any ring nitrogen atom may be quaternised or oxidised;
alternatively, any two substituents of the group A may combine to form a fused 5- or 6-membered saturated or partially saturated carbocyclic or heterocyclic ring in which any carbon or quaternised nitrogen atom may be substituted with any of the groups defined herein for A or in which a ring carbon atom may be oxidised;
the process comprising cyclising a compound of general formula VII: ##STR2## wherein A, R.sup.2 and R.sup.3 are as defined for general formula II, R.sup.20 is hydrogen, benzyl or benzyl substituted with up to five substituents selected from halo, C.sub.1 -C.sub.6 alkyl, O(C.sub.1 -C.sub.6 alkyl) or nitro and R.sub.21 is C.sub.1 -C.sub.8 alkyl, benzyl or benzyl substituted with up to five of the substituents mentioned above for R.sup.20.
Cox John Michael
Ellis Russell
Kozakiewicz Anthony Marian
Langton David William
Mitchell Glynn
Oswecki Jane C.
Richter Johann
Snyder Joseph R.
Zeneca Limited
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