Cyclization process for .beta.-lactams

Details Cyclization process for .beta.-lactams Cyclization process for .beta.-lactams

1985-10-03

1987-06-23

Beron, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D41112

Patent

active

046753990

ABSTRACT:
Process for N-acyloxy or sulfooxy 2-azetidinones comprising O-acylation of a .beta.-hydroxy or .beta.-halo hydroxamic acid, and cyclizing the O-acylhydroxamate with TPP-CCl.sub.4 -TEA or with TPP-dialkylazodicarboxylate to the N-acyloxy-2-azetidinone. Solvolysis of the acyl group provides an N-hydroxy-2-azetidinone. e.g., N-Cbz-L-serine is converted to the O-acetyl hydroxamate, cyclized and solvolyzed to N-hydroxy-3-(Cbz-amino)-2-azetidinone. The N-hydroxy-2-azetidinones are useful intermediates to monocyclic .beta.-lactam antibiotics and .beta.-lactamase inhibitors.

REFERENCES:
patent: 4337197 (1982-06-01), Gordon et al.

Affiliated with

Also associated with

Rating

Cyclization process for .beta.-lactams does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclization process for .beta.-lactams, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclization process for .beta.-lactams will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-722178