Cyclization of peptides

Details Cyclization of peptides Cyclization of peptides

1975-11-12

1977-07-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

040339408

ABSTRACT:
The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing an amino terminal cystine residue and a cysteine residue located in a position within the amino acid sequence, to give a desired peptide, and placing such intermediate peptide in a solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace a molecule of cysteine from the amino terminal cysteine residue. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

REFERENCES:
patent: 3929758 (1975-12-01), Hughes et al.
Hiskey et al.: J. Org. Chem., 35, 1118-1121 (1970).

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