Cyclization of peptides

Details Cyclization of peptides Cyclization of peptides

1978-11-13

1980-07-15

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125S, 2601125R, C07C10352

Patent

active

042127955

ABSTRACT:
The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

REFERENCES:
patent: 3929758 (1975-12-01), Hughes et al.
patent: 3988309 (1976-10-01), Matsuda et al.
patent: 4033940 (1977-07-01), Hughes et al.

Affiliated with

Also associated with

Rating

Cyclization of peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclization of peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclization of peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-463455