Cyclization for preparing antifolate compounds

Details Cyclization for preparing antifolate compounds Cyclization for preparing antifolate compounds

1993-07-23

1999-10-19

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546212, 546214, 546221, C07D48704, C07D40506, C07D40906, C07D21178

Patent

active

059691360

ABSTRACT:
This invention provides a process for preparing a compound of formula III ##STR1## wherein R.sup.1 is bromo, iodo or COOR.sup.2 ;

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Snider, T.E., et al., Org. Prep. and Procedures Int., 4(5):237-245 (1972).
DeGraw, J., et al., Canadian J. Chem., 41:3137-3139 (1963).

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