Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1999-02-10
2000-02-29
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435194, 4353201, 435325, 4352523, 530350, C12Q 168, C12N 912, C12N 120, C12N 1500, C12N 500
Patent
active
060307889
ABSTRACT:
An isolated nucleic acid molecule is disclosed which encodes a novel human cyclin-dependent kinase (CDK) which comprises a novel cyclin binding domain signature sequence and lacks several heretofore conserved amino acid residues involved in regulation of the cdk/cyclin complex. Associated proteins and biologically active mutant forms are also disclosed.
REFERENCES:
Kobayashi et al. "Identification of the Domains in Cyclic A Required for Binding to, and Activation of, p34 (cdc2) and p32(cdk2) Protein Kinase Subunits", Molecular Bioblogy of the Cell, vol. 3, 1279-1294, Nov. 1992.
Lees et al. "Sequences within the Conserved Cyclic Box of Human Cyclin A Are Sufficient for Binding to and Activation of cdc2 Kinase", Molecular and Cellular Biology, vol. 13 Feb. 1993, pp 1194-1201.
Poon et al. "Cell cycle regulation of the p34(cdc2)/p33(cdk2)-activating kinase p40(MO15)", Jour. of Cell Science 107, 2789-2799 (1994).
Fisher et al. "A Novel Cyclin Associates with MO15/CDK7 to Form the CDK-Activating Kinase", Cell, vol. 78, pp 713-724 Aug. 26, 1994.
Morgan et al. "Principles of CDK regulation", Nature, vol. 374, pp 131-134 Mar. 9, 1995.
van der Heuvel et al. "Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control", Science, vol. 262, Dec. 24, 1993.
Wilson, 1995, The Wash U-Merck EST Project, dbEST 277665, GenBank Acc. No. H17727.
Pines, Reaching for a role for the Cks protiens; Current Biology; 1996, vol. 6, No. 11; pp 1399-1402.
Morgan, The dynamics of cyclin dependent kkinase structure; Current Opinion in Cell Biology; 1996; 8: 767-772.
Brambilla et al., Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases; Oncogene, vol. 9, pp 3037-3041, 1994.
Achutamurthy Ponnathapu
Hand J. Mark
Merck & Co. , Inc.
Monshipouri M.
Tribble Jack L.
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