Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-09-19
2010-10-05
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S007230, C514S002600
Reexamination Certificate
active
07807368
ABSTRACT:
The present invention provides methods of cell cycle control by administering opioid growth factor (OGF), which activates opioid growth factor receptor (OGFr) signaling. Particularly, the present invention provides a method for monitoring OGF modulation or treatment of a cell proliferation or growth related condition in a subject by assessing the level of the cyclin dependent kinase inhibitor (CKI) relevant or corresponding to the condition. The present invention also provides a method for screening the eligibility of a subject for OGF modulation or treatment by assessing the level of OGF receptor (OGFr) and the relevant CKI. A method for enhancing the efficacy of OGF therapy by increasing the level of the relevant CKI and/or OGFr is also provided.
REFERENCES:
patent: 4537878 (1985-08-01), Plotnikoff
Zagon et al., Cancer Letters, Jan. 30, 1997;112(2):167-75.
McLaughlin et al., Cancer Letters (2003) vol. 199, pp. 209-217.
Abbruzzese, J (2002) Cancer, vol. 95, pp. 941-945.
Cheng F. et al., “The Opioid Growth Factor (OGF)—OGF Receptor Axis Uses the p16 Pathway to Inhibit Head and Neck Cancer”,Cancer Research67(21):10511-10518 (2007).
Cheng F. et al., “The OGF-OGFr Axis Utilizes the p21 Pathway to Restrict Progression of Human Pancreatic Cancer”,Molecular Cancer7(5):1-12 (2008).
Donahue R.N. et al., “Cell Proliferation of Human Ovarian Cancer is Regulated by the Opioid Growth Factor-Opioid Growth Factor Receptor Axis”,Am J Physiol Regul Integr Comp Physiol 296:R1716-R1725 (2009).
Cheng F. et al., “The OGF-OGFr Axis Utilizes the p16INK4aand p21WAF1/CIP1Pathways to Restrict Normal Cell Proliferation”,Molecular Biology of the Cell20:319-327 (2009).
Zagon I.S. et al., “The Biology of the Opioid Growth Factor Receptor (OGFr)”,Brain Research Reviews38:351-376 (2002).
McLaughlin Patricia J.
Verderame Michael F.
Zagon Ian S.
Scully , Scott, Murphy & Presser, P.C.
Yu Misook
LandOfFree
Cyclin-dependent kinase inhibitors as targets for opiod... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclin-dependent kinase inhibitors as targets for opiod..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclin-dependent kinase inhibitors as targets for opiod... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4173452