Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-02-28
1996-05-07
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 6, 4351721, C12N 1501, C12N 1509, C12N 1564
Patent
active
055145710
ABSTRACT:
Use of cyclin D1 as a negative regulator of cell proliferation is disclosed. Overexpression of cyclin D1 blocks cell growth, while blocking cyclin D1 expression promotes cell proliferation.
REFERENCES:
Baldin, B., Lukas, J., Marcote, M. J., Pagano, M. and Draetta, G. "Cyclin D1 is a nuclear protein required for cell cycle progression in G.sub.1" Genes & Development 7, 812-821 (1993).
Dowdy, S., F., Hinds, P. W., Louie, K., Reed, SI., Arnold, A. and Weinberg, R. A., "Physical Interaction of the Retinoblastoma Protein with Human D Cyclins", Cell 73, 499-511 (1993).
Draetta, G., "Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation", Trends Biol. Sci. 15, 378-383 (1990).
Dulic, V., Lees, E. and Reed, S. I., "Association of Human Cyclin E with a Periodic G.sub.1-S Phase Protein Kinase", Science 257, 1958-1961 (1992).
Ewen, M. E., Sluss, H. K., Sherr, C. J. Matsushime, H., Kato, J. and Livingston, M. D., "Functional Interactions of the Retinoblastoma Protein with Mammalian D-type Cyclins", Cell 73487-497 (1993).
Faust, J. B. and Meeker, T. C., "Amplification and Expression of the bcl-1 Gene in Human Solid Tumor Cell Lines", Cancer Res. 52, 2460-2463 (1992).
Giordano, A. et al., "A 60 kd cdc2-Associated Polypeptide Complexes with the E1A Proteins in Adenovirus-Infected Cells", Cell 58, 981-990 (1989).
Girard, F., Strausfeld, U., Fernandez, H. and Lamb, J., "Cyclin A is Required for the Onset of DNA Replication in Mammalian Fibroblasts", Cell 67, 1169-1179 (1991).
Goldstein, S., "Replicative Senescence: The Human Fibroblast Comes of Age", Science 249, 1129-1133 (1990).
Hayflick, L., and Moorhead, P. S., "The Serial Cultivation of Human Diploid Cell Strains.sup.1", Exp. Cell Res. 25, 585-621(1961).
Hayflick, L., "The Limited In Vitro Lifetime of Human Diploid Cell Strains.sup.1,2", Exp. Cell Res. 37, 614-636 (1965).
Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. and Weinberg, R., "Regulation of Retinoblastoma Protein Functions by Ectopic Expression of Human Cyclins", Cell 70, 993-1006 (1992).
Jiang, W. et al., "Amplification and Expression of the Human Cyclin D Gene in Esophageal Cancer.sup.1," Cancer Res. 52, 2980-2983 (1992).
Kiyokawa, H. et al., "Cloning of a D-type cyclin from murine erythroleukemia cells", Proc. Natl. Acad. Sci. 89, 2444-2447 (1992).
Koff, A., Cross, F., Fisher, a., Schumacher, J., Leguellec, K., Philippe, M. and Roberts, J. M., "Formation and Activation of a Cyclin E-cdk2 Complex During the G.sub.1 Phase of the Human Cell Cycle", Cell 66, 1217-1228 (1991).
Koff, A., Ohtsuki, M., Polyak, K., Roberts, J. M. and Massague, J., "Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-.beta.", Science 260, 536-539 (1993).
Koff, A. et al., "Human Cyclin E, a New Cyclin that Interacts with Two Members of the CDC2 Gene Family", Science 257, 1689-1694 (1992).
Lamb, N. J. C., Fernandez, A., Watrin, A., Labbe, J. C. and Cavadore, J. C., "Microinjection of p34.sup.cdc2 Kinase Induces Marked Changes in Cell Shape, Cytoskeletal Organization, and Chromatin Structure in Mammalian Fibroblasts", Cell 60, 151-165 (1990).
Lew, D. J., Dulic, V. and Reed, S. I., "Isolation of Three Novel Human Cyclins by Rescue of G1 Cyclin (Cln) Function in Yeast", Cell 66, 1197-1206 (1991).
Matsushime, H., Roussel, M. F., Ashmun, R. A. and Sherr, C. J., "Identification and Properties of an Atypical Catalytic Subunit (p34.sup.PSK-J3 /cdk4) for Mammalian D Type G1 Cyclins", Cell 65, 701-713 (1991).
Matsushime, H. et al., "Colony-Stimulating Factor 1 Regulates Novel Cyclins During the G1 Phase of the Cell Cycle", cell 71, 323-334 (1992).
Motokura, T. et al., "A novel cyclin encoded by a bc/1-linked candidate oncogene", Nature 350, 512-515 (1991).
Ohtsubo, M. and Roberts, J. M. "Cyclin-Dependent Regulation of G.sub.1 in Mammalian Fibroblasts", Science 259, 1908-1912 (1993).
Pagano, M., Peppercock, P., Verde, F., Ansorge, W. And Draetta, G., "Cyclin A is required at two points in the human cell cycle", EMBO J. 11, 961-971 (1992).
Pines, J. and Hunter, T., "Human Cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B", Nature 346, 760-763 (1990).
Quelle, D. E., et al., "Overexpression of mouse D-type cyclins accelerates G.sub.1 phase in rodent fibroblasts", Genes & Development 7, 1559-1571 (1993).
Riabowol, K. T. et al., "The catalytic subunit of CAMP-dependent protein kinase induces expression of genes containing CAMP-responsive enhancer elements" Nature 336, 83-86 (1988).
Riabowol, K. T., Schiff, J. and Gilman, M. Z., "Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging", Proc. Natl. Acad. Sci. 89, 157-161 (1992).
Riabowol, K. T., Draetta, G., Brizuela, L., Vandre, D. and Beach, D., "The cdc2 Kinase is a Nuclear Protein That is Essential for Mitosis in Mammalian Cells", Cell 57, 393-401 (1989).
Richter, K. H. et al., "Down-Regulation of cdc2 in Senescent Human and Hamster Cells", Cancer Res. 51, 6010-6013 (1991).
Rosenthal, E. T., Hunt, T. and Ruderman, J. V., "Selective Translation of mRNA Controls the Pattern of Protein Synthesis during Early Development of the Surf Clam, Spisula solidissima", Cell 20, 487-494 (1980).
Stein, G. H., Drullinger, L. F., Robetorye, R. S., Pereira-Smith, O. M. and Smith, J. R., "Senescent cells fail to express cdc2, cycA, and CycB in response to mitogen stimulation", Proc. Natl. Acad. Sci. USA 88, 11012-11016 (1991).
Tsai, L-H., Lees, E., Faha, B., Harlow, E. and Riabowol, K., "The cdk2 kinase is requird for the G1-to-S transition in mammalian cells", Oncogene 8, 1593-1602 (1993).
Tsai, L-H., Harlow, E. and Meyerson, M., "Isolation of the human cdk2 gene that encodes the cyclin A-and adenovirus E1A-associated p33 kinase", Nature 353, 174-177 (1991).
Walker D. H. and Maller, J. L., "Role for cyclin A in the dependence of mitosis on completion of DNA replication", Nature 354, 314-317 (1991).
Withers, D. A. et al., "Characterization of a Candidate bcl-1 Gene", Mol. Cell Biol. 11, 4846-4853 (1991).
Won, K-A., Xiong, Y., Beach, D. and Gilman, M. Z., "Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts", Proc. Natl. Acad. Sci. 89, 9910-9914 (1992).
Xiong, Y., Connolly, T., Futcher, B. and Beach, D., "Human D-Type Cyclin", Cell 65, 691-699 (1991).
Xiong, Y., Zhang, H. and Beach, D., "D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA", Cell 71, 505-514 (1992).
Xiong, Y., et al. "Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation", Genes & Development 7, 1572-1583 (1993).
Yang, Y., Raper, S. E., Cohn, J. A., Engelhardt, J. F. and Wilson, J. M., "An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer", Proc. Nat'l. Acad. Sci. USA 90, 4601-4605 (1993).
Zindy, F. et al. "Cyclin A is Required in S Phase in Normal Epithelial Cells", Biophys. Res. Commum. 182, 1144-1154 (1992).
Fleisher Mindy
Ketter James
University Technologies International Inc.
LandOfFree
Cyclin D1 negative regulatory activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclin D1 negative regulatory activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclin D1 negative regulatory activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1226616