Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-09-21
1999-11-09
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C06K 100
Patent
active
059817020
ABSTRACT:
The present invention relates to the discovery in mammalian cells, particularly human cells, of novel S-phase kinase associated proteins, p19 and p45, referred to herein as "Skp". As described herein, these proteins are components of the tumor cell-specific cyclin A/CDK2 complex and function to facilitate DNA replication. Interference with p45 function in vivo prevented entry into S-phase in both normal and transformed cells. Binding data indicated that p45 and p19 associate with each other in a binary complex. Moreover, p45 is required for p19 binding to cyclin A/CDK2.
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Beach David
Zhang Hui
Achutamurthy Ponnathapura
Cold Spring Harbor Laboratory
Monshipouri Maryam
Varma Anita
Vincent Matthew P.
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