Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-09-10
2000-07-04
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514269, 544123, 544316, A61K 31535, A61K 31505, C07D23910
Patent
active
060839457
ABSTRACT:
Disclosed are cyclic urea-containing compounds that are useful as antiarrhythmic and/or antifibrillatory agents. These compounds have the following structure: ##STR1## where X and Y are each independently selected from various cyclic moieties; R.sub.5 is a substituted or unsubstituted C.sub.2 alkyl (thus providing a 6-membered cyclic urea); and R.sub.1, R.sub.2, R.sub.3, R.sub.4, L, and A are as defined in the specification. Also disclosed are compositions containing the compounds and methods of treating humans or other mammals afflicted with cardiac arrhythmias and/or cardiac fibrillation by administration of the compounds/compositions.
REFERENCES:
patent: 3254075 (1966-05-01), Ebetino
patent: 3992374 (1976-11-01), Rufer et al.
patent: 5462940 (1995-10-01), Yu et al.
patent: 5691369 (1997-11-01), Pelosi, Jr. et al.
Pelosi, Jr. Stanford Salvatore
Yu Chia-Nien
Clark Karen F.
Kifle Bruck
Roof Carl J.
Shah Mukund J.
Suter David L.
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