Cyclic sulfonyl compounds as inhibitors of metalloproteases

Details Cyclic sulfonyl compounds as inhibitors of metalloproteases Cyclic sulfonyl compounds as inhibitors of metalloproteases

2005-08-09

2005-08-09

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S314000, C514S342000, C514S372000, C544S003000, C546S172000, C546S271100, C548S111000, C548S206000, C548S213000, C548S214000

Reexamination Certificate

active

06927216

ABSTRACT:
The present application describes novel cyclic sulfonyl derivatives of formula I:or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.

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CAPLUS printout for EP 0 342 456, Nov. 23, 1989.
Luisi, G. et al, Pseudopeptides containing isothiazolidine-1, 1-dioxide-3-carboxylic acid: synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analog of pyroglutamic acid, Archiv. Der. Pharmazie, vol. 326, no 3, 1993, pp. 139-141.

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