Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-10-31
2008-09-23
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S278000, C514S362000, C546S016000, C548S126000
Reexamination Certificate
active
07427621
ABSTRACT:
Compounds of formula I:inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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Patini et al, Chem Rev. 1996, 96, 3147-3176.
G. Rishton et al.,m “Fenchylamine Sulfonamide Inhibitors of Amyloid Beta Peptide Production by the Gamma-Secretase Proteolytic Pathway: Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease”, J. Med Chem., vol. 43, pp. 2297-2299 (2000).
Collins Ian James
Hannam Joanne Clare
Harrison Timothy
Madin Andrew
Ridgill Mark Peter
Chung Susannah
Krovatin William
Merck Sharp & Dohme Limited
Shiao Rei-tsang
Yuro Raynard
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