Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1972-11-06
1976-08-31
Todd, G. Thomas
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260244A, 2602564F, 424251, C07D48704
Patent
active
039780597
ABSTRACT:
The compounds are biologically active tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones, pyrimido[2,1-b]quinazolin-6-ones and diazepino[2,1-b]quinazolin-7-ones substituted by a thienyl or furyl group, e.g., 10-(2-thienylmethyl)-2,3-dihydro-imidazo[2,1-b] quinazolin-5(10)-one, and useful, for example, as broncho-dilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with a cyclic pseudothiourea such as 2-organomercapto-4,5-dihydroimidazole or 2-organomercapto-3,4,5,6-tetrahydropyrimidine.
REFERENCES:
patent: 3309369 (1967-03-01), Schindler
patent: 3313815 (1967-04-01), Wolfe et al.
patent: 3379733 (1968-04-01), Houlihan
patent: 3470180 (1969-09-01), Houlihan
patent: 3600390 (1971-08-01), Sherlock
Sandoz Inc.
Sharkin Gerald D.
Todd G. Thomas
Vila Richard E.
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