Cyclic somatostatin disulfide analogues

Details Cyclic somatostatin disulfide analogues Cyclic somatostatin disulfide analogues

1976-01-30

1976-12-14

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

039975177

ABSTRACT:
Cyclized somatostatin analogues containing the Cys-Cys disulfide linkage, their pharmaceutically acceptable acid addition salts as well as their cyclic disulfhydryl precursors and intermediates therefor are disclosed. The cyclized analogues of somatostatin selectively reduce blood serum concentrations of growth hormone without materially affecting the concentrations of glucagon or insulin.

REFERENCES:
patent: 3931140 (1976-01-01), Sarantakis

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