Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-

Details Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)- Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-

1991-06-11

1993-10-19

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540454, 540460, 540463, C07D22500

Patent

active

052546829

ABSTRACT:
Compounds of the formula: ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.

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Bolis et al., Renin Inhibitors, J. Med. Chem., 30, pp. 1729-1737 (1987).
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