Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, proces

Details Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, proces Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, proces

1990-08-23

1993-08-31

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 5142278, 5142315, 5142322, 514255, 514340, 514341, 514342, 540544, 540575, 544 60, 544 78, 544360, 546275, 546278, 546280, 546193, 546194, C07D24304, C07D26708, C07D40114, A61K 3144

Patent

active

052409210

ABSTRACT:
The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.

REFERENCES:
patent: 4987132 (1991-01-01), Mase et al.
patent: 5037839 (1991-08-01), Bickel et al.
S. Botros et al., Chemical Abstracts, vol. 108, 1988, p. 725, abstract No. 150265c.
E. Buhleier et al., Chem. Ber., vol. 112, 1979, pp. 559-566, Verlag Chemie, GmbH, Weinheim, Del.

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