Cyclic prodrugs of peptides and peptide nucleic acids having imp

Details Cyclic prodrugs of peptides and peptide nucleic acids having imp Cyclic prodrugs of peptides and peptide nucleic acids having imp

1995-04-25

1997-09-30

Johnson, Jerry D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3802

Patent

active

056725841

ABSTRACT:
Provided are cyclic prodrugs of biologically active peptides and peptide nucleic acids exhibiting improved cell membrane permeability and enzymatic stability, containing 3-(2'-hydroxy-4',6'-dimethyl phenyl)-3,3-dimethyl propionic acid and its deriveatives and acyloxyalkoxy linkers. Also provided are pharmaceutical compositions containing effective amounts of these cyclic prodrugs in combination with pharmaceutically acceptable carriers, excipients, or diluents.

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