Cyclic polypeptides having mu-receptor specificity

Details Cyclic polypeptides having mu-receptor specificity Cyclic polypeptides having mu-receptor specificity

1984-09-04

1987-08-04

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530809, 530329, 530302, A61K 3743, C07K 712, C07K 706

Patent

active

046846204

ABSTRACT:
Novel compounds which are capable of binding with enhanced specificity to the mu opioid receptor are disclosed. The compounds are analogs of somatostain and have the formula: ##STR1## wherein X is CONH.sub.2 or CH.sub.2 OH;

REFERENCES:
patent: 4282143 (1981-08-01), Sarantakis
patent: 4395403 (1983-07-01), Bauer et al.
patent: 4496543 (1985-01-01), Bauer et al.
Maurer et al., "Opiate Antagonistic Properties of an Octapeptide Somatostatin Analog," Proc. Natl. Acad. Sci. USA 79, 4815 (1982).

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