Cyclic phosphonate ester inhibitors of microsomal triglyceride t

Details Cyclic phosphonate ester inhibitors of microsomal triglyceride t Cyclic phosphonate ester inhibitors of microsomal triglyceride t

1998-10-20

1999-10-05

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

544157, 546 22, 548113, 558 83, A61K 31675, A61K 3166, C07F 96574, C07F 96541

Patent

active

059624400

ABSTRACT:
Novel cyclic phosphonate ester inhibitors of MTP are provided which have the structure ##STR1## wherein R.sup.2, L.sup.2, A, B, L.sup.1, R.sup.1 and R.sup.5a are as set out herein. These compounds are useful in lowering serum cholesterol and triglycerides.

REFERENCES:
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Bentrude, W.G. et al, "Conformations of Saturated Cyclic Phosphorus Heterocycles, II, 5-tert-Butyl-2-amino-1,3,2-dioxaphosphorinanes, Apparent Effects of P-N Vicinal Interactions on the Conformational Energy of Amino Groups on Trivalent Phosphorus . . . ", J. of the Amer. Chem. Soc. 95:14, Jul. 11, 1973, pp. 4666-4675.
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