Cyclic peptidomimetic urokinase receptor antagonists

Details Cyclic peptidomimetic urokinase receptor antagonists Cyclic peptidomimetic urokinase receptor antagonists

2008-01-01

2008-01-01

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S011400

Reexamination Certificate

active

11321534

ABSTRACT:
The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.

REFERENCES:
patent: WO 97 12905 (1997-05-01), None
patent: WO 98 21230 (1998-04-01), None
patent: WO 98 46632 (1998-10-01), None
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
Dermer (Bio/Technology, 1994, 12:320).
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Sato S, et al, “High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread,” FEBS Lett. Sep. 25, 2002;528(1-3):212-6, Applicant's IDS.
Magdolen, V. et al., “Systematic Mutational Analysis of the Receptor-Binding Region of the Human Urokinase-Type Plasminogen Activator”, European Journal of Biochemistry, DE, Berlin, Vo. 237, 1996, pp. 743-751.
Sato et al., “High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread”, FEBS Letters 528 (2002), 212-216.

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