Cyclic peptides that bind to urokinase-type plasminogen activato

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 9, 530317, 530323, 530327, A61K 3812, A61K 3808, A61K 3800

Patent

active

059424923

ABSTRACT:
Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C.sup..alpha. carbon of the first amino acid and the C.sup..alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.

REFERENCES:
Bowie et al. (1990) Science 247: 1306-1310, Mar. 1990.
Stryer et al. (1988) Biochemistry, 3.sup.rd Edition. W.H. Freeman and Company, New York, pp. 17, 25-28.
Markus Burgle et al., "Inhibition of the Interaction of Urokinase-Type Plasminogen Activator (uPA) with its Receptor (uPAR) by Synthetic Peptides", Biological Chemistry, vol. 378, Mar./Apr. 1997, pp. 231-237.
Appella, E. et al., J. Biol. Chem., 262:4437-40 (1987).
Behrendt, N. et al., Biol. Chem. Hoppe-Seyler, 376:269-79 (1995).
Behrendt, N. et al., J. Biol. Chem. 265:6453-6460 (1990).
Behrendt, N. et al., J. Biol. Chem. 268:5985-5989 (1993).
Billstrom et al., Int. J. Cancer, 61:542-47 (1995).
Bridges, Bioorganic & Medicinal Chemistry, 1:403-410 (1993).
Chamberlin et al., J. Biol. Chem., 270:21062-21067 (1995). Application!.
Dan.o slashed., K. et al., Adv. Cancer Res., 44:139-266 (1985).
Dumler, I. et al., FEBS Lett. 322:37-40 (1994).
Ellis, V. et al., J. Biol. Chem., 264:2185-88 (1989).
Faziolo, F. et al., Trends Pharmacological Sci., 15:25-29 (1994).
Geratz et al., Thrombosis Res. 24:73-83 (1981).
Goodson, R.J. et al., Proc Natl Acad Sci USA 91:7129-7133 (1994).
Hansen et al., Biochemistry, 33:4847-64 (1994).
Hansen, A.P. et al., Biochemistry 33:15418-15424 (1994).
He, C. et al., Proc. Natl. Acad. Sci. USA, 86:2632-36 (1989).
Hunter et al., Protein Sci., 4:2129-37 (1995).
Kellen et al., Anticancer Res. 8:1373-76 (1988).
Kobayashi, H. et al., Int. J. Cancer, 57:727-33 (1994).
Leszczynski, J.F. et al., Science 234:849-855 (1986).
Lougheed et al., Protein Sci., 4: 773-80 (1995).
Lu, H. et al., FEBS Lett. 380:21-24 (1996).
Magdolen et al., "Systematic Mutational Analysis of the Receptor-binding Region of the Human Urokinase-type Plasminogen Activator", Eur. J. Biochem., 237:743-51 (1996).
Mandriota, S.J. et al., J. Biol. Chem., 270:9709-9716 (1995).
Matrisian, L.M. Bioessays, 14:455-63 (1992).
Mazar, A.P. et al., Fibrinolysis 6 (Suppl. 1):49-55 (1992).
Mignatti, P. et al., Cell, 47:487-98 (1986).
Mignatti, P. et al., J. Cell Biol., 113:1193-1201 (1991).
Min et al., Cancer Res., 56:2428-33 (1996).
Montesano, R. et al., Proc. Natl. Acad. Sci. USA, 83:7297-7301 (1986).
Odekon, L.E. et al., J. Cellul. Physiol., 150:258-63 (1992).
Pepper, M.S. et al., Biochem. Biophys. Res. Comm., 181:902-906 (1991).
Rabbani, S.A. et al., Int. J. Cancer, 63:840-45 (1995).
Rabbani, S.A. et al., J. Biol. Chem., 267:14151-56 (1992).
Rao, N.K. et al., J. Clin. Invest. 96:465-74 (1995).
Rizo, J. et al., Ann. Rev. Biochem. 61:387-418 (1992).
Robbiati et al., Fibrinolysis, 4:53-60 (1990).
Robbins, K.C. Meth. Enzymol., 19:184-99 (1970).
Ronday et al., Br. J. Rheum., 35:416-423 (1996).
Schnaper, H.W. et al., J. Cellul. Physiol. 165:107-118 (1995).
Stoppelli et al., Proc. Natl. Acad. Sci. USA 82:4939-43 (1985).
Stratton-Thomas et al., Protein Engineering 8:463-70 (1995).
Towle et al., Cancer Res., 53:2553-59 (1993).
Vassalli et al., FEBS Lett., 214:187-191 (1987).
Wang, N. et al., Am. J. Physiol. 268:C1062-C1066 (1995).
Werb, Z. et al., N. Eng. J. Med., 296:1017-1023 (1977).
Yang, H. et al., Fibrinolysis, 6 (Suppl. 1):31-34, (1992).
Yang, H. et al., J. Med. Chem., 33:2956-61 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclic peptides that bind to urokinase-type plasminogen activato does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic peptides that bind to urokinase-type plasminogen activato, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic peptides that bind to urokinase-type plasminogen activato will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-467079

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.