Cyclic peptides, method for preparing and use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S009340

Reexamination Certificate

active

10381734

ABSTRACT:
The invention relates to cyclopeptides, the method of their preparation and their utilization as inhibitors or activators of angiogenesis.These cyclopeptides comprise the following peptide sequence:in-line-formulae description="In-line Formulae" end="lead"?-Arg-Ile-Lys-Pro-His-Gln-Gly-in-line-formulae description="In-line Formulae" end="tail"?They can be used in systems for inhibition of angiogenesis that comprises a support (1), to which the cyclopeptide is affixed by means of an organic spacer arm (3) that may be provided with a moiety (4) capable of being spliced by an enzyme system.

REFERENCES:
patent: 5849692 (1998-12-01), Jonczyk et al.
patent: 5939383 (1999-08-01), Remacle et al.
patent: 0 844 252 (1998-05-01), None
patent: 99 40947 (1999-08-01), None
patent: 00 53219 (2000-09-01), None
B. Ivanov et al.: “Synthesis and use of a new bromoacetyl-derivatized heterotrifunctional amino acid for conjugation of cyclic RGD-containing peptides derived from human bone sialoprotein” Bioconjugate Chemistry, vol. 6, pp. 269-277, 1995.
D. Delforge et al.: “Solid-phase synthesis of tailed cyclic peptides: the use of alpha-allyl-protected aspartic acid leads to aspartimide and tetramethylguanidium formation” Letter In Peptide Science, vol. 3, pp. 89-97, May 1, 1996.
S.A. Kates et al.: “Automated allyl cleavage for continuous-flow synthesis of cyclic and branched peptides” Analytical Biochemistry, vol. 212, pp. 303-310 1993.
LG Presta et al.: “Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders” Cancer Res., vol. 57, No. 20, pp. 4593-4599, Oct. 1997.
N. Ortega et al.: “Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectivity triggers endothelial cells with an angiogenic phenotype” Am J Panthol, vol. 151, No. 5, pp. 1215-1224, Nov. 1997.
Yves A. Muller et al.: “The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding” Structure, vol. 5, NO. 10, pp. 1325-1338, Oct. 15, 1997.
Svitlana Chetyrkina et al.: “Synthesis of N-Fmoc-4-[(diethylphosphone)-2′, 2′-difluoro-1′-hydroxyethyl]phenylalanine, a novel phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides” Tetrahedron Letters vol. 41, pp. 1923-1926, 2000.
Roselyne Binetruy-Tournaire et al.: “Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis” The EMBO Journal, vol. 19, No. 7, pp. 1525-1533, 2000.
Martin Hagedorn et al.: “Target molecules for anti-angiogenic therapy: from basic research to clinical trials” Critical Reviews in Oncology/Hematology, vol. 34, pp. 89-110, 2000.
Christine Piossek et al.: “Vascular endothelial growth factor (VEGF) receptor II-derived peptides inihibit VEGF” The Journal of Biological Chemistry, vol. 274, No. 9, pp. 5612-5619 1999.
Frederic Jonca et al.: “Cell release of bioactive fibroblast growth factor 2 by exon 6-encoded sequence of vascular endothelial growth factor” The Journal of Biological Chemistry, vol. 272, No. 39, pp. 24203-24209, 1997.
Napoleone Ferrara et al.: “Clinical applications of angiogenic growth factors and their inhibitors” Nature Medicine, vol. 5, No. 12, pp. 1359-1364, Dec. 1999.
D. Scott Wilbur et al.: “Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrimers” Bioconjugate Chem., vol. 9, pp. 813-825, 1998.
Katherine D. McReynolds et al.: “Syntehsis of biotinylated glycoconjugates and their use in a novel ELISA for direct comparison of HIV-1 Gp120 recognition of GalCer and related carbohydrate analogues” Bioconjugate Chem., vol. 10, pp. 1021-1031, 1999.
Yasufumi Sato et al.: “Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement plasminogen activator synthesis, and DNA synthesis” The Journal of Cell Biology, vol. 107, pp. 1199-1205, Sep. 1988.
Oliver Seltz et al.: “HYCRON, an allylic anchor for high-efficiency solid phase synthesis of protected peptides and glycopeptides” J. Org. Chem., vol. 62, pp. 813-826, 1997.
Wayne J. Fairbrother et al.: “Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site” Biochemistry, vol. 37, pp. 17754-17764, 1998.
Bertrand Carboni et al.: “Aliphatic amino azides as key building blocks for efficient polyamine syntheses” J. Org. Chem., vol. 58, pp. 3736-3741 1993.
Haimanot Bekele et al.: “Improved synthesis of the Boc and Fmoc derivatives of 4-(4′-aminoethyl)-6-dibenzofuranpropionic acid: an unnatural amino acid that nucleates beta-sheet folding” J. Org. Chem., vol. 62, pp. 2259-2262, 1997.

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