Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-11-14
1999-08-17
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 530317, A61K 3800, A61K 3812, C07K 500, C07K 700
Patent
active
059393831
ABSTRACT:
A cyclic peptide includes a dicarboxylic amino acid. The cyclic peptide bears at least one tail for subsequent coupling on a solid support, on a high molecular weight compound, on a marker, or on one or more other similar or different cyclic peptides. The present invention is also related to the preparation process of the cyclic peptide and to a biomaterial which includes the cyclic peptide.
REFERENCES:
Delforge et al, Analytical Biochemistry, vol. 242, pp. 180-186, 1996.
D. Delforge et al; "Solid-Phase Synthesis of Tailed Cyclic Peptides: The Use of .alpha.-allyl-protected Aspartic Acid Leads to Aspartimide and Tetramethylguanidinium Formation"; Letters in Peptide Science; vol. 3, No. 2; May 1996; pp. 89-97; XP-002063392.
M. Art et al; "Synthesis of Linear and Cyclic RGD-Peptides For The Purpose of Their Chemical Grafting On Poorly Adhesive Polymers Such as Polyethylene Terephtalate"; Polym. Preprints; vol. 36, No. 1; Apr. 1995; pp. 115-116; XP-002063393.
D. Delforge et al; "Automated solid-phase synthesis of cyclic peptides bearing a side-chain tail designed for subsequent chemical grafting"; Analytical Biochemistry; vol. 242, Nov. 15, 1996; pp. 180-186; XP-002063394.
S. A. Kates et al.; "Automated Allyl Cleavage for Continuous-Flow Synthesis of Cyclic and Branched Peptides"; Analytical Biochemistry; vol. 212; 1993; pp. 303-310; XP-002063395.
B. Ivanov et al.; "Synthesis and Use of a New Bromoacetyl-Derivatized Heterotrifunctional Amino Acid for Conjugation of Cyclic RGD-Containing Peptides Derived from Human Bone Sialoprotein"; Bioconjugate Chem.; vol. 6 1995; pp. 269-277; XP-002063396.
H.F. Brugghe et al; "Simultaneous Multiple Synthesis and Selective Conjugation of Cyclized Peptides Derived From a surface Loop of a Meningococcal Class 1 Outer Membrane Protein"; International Journal of Peptide and Protein Research; vol. 43; 1994; Copenhagen, Denmark; pp. 166-172; XP-002063397.
Delforge Dominique
Remacle Jose
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