Cyclic peptides as potent and selective melanocortin-4...

Details Cyclic peptides as potent and selective melanocortin-4... Cyclic peptides as potent and selective melanocortin-4...

2005-11-01

2005-11-01

Lukton, David (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C530S330000, C514S011400, C514S017400, C514S018700

Reexamination Certificate

active

06960646

ABSTRACT:
Cyclic peptides of formula I are potent and selective agonists of melanocortin-4 receptors, and as such are useful research tool for the determination of the physiological roles of the MC-4 receptor, as well as for the diagnoses, treatment or prevention of disorders or diseases mediated through the MC-4 receptor.

REFERENCES:
patent: 2002/0143141 (2002-10-01), Li et al.
Arian Wai-Hing Cheung, et al.,Bioorganic&Medicinal Chemistry Letters, 13, pp. 1307-1311, (2003).
Malcolm J. Kavarana, et al.,J. Med. Chem., 45, pp. 2644-2650, (2002).
Maria A. Bednarek, et al.,Biochemical and Biophysical Research Communications, 286, pp. 641-645, (2001).

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