Cyclic peptide with anti-metastasis activity

Details Cyclic peptide with anti-metastasis activity Cyclic peptide with anti-metastasis activity

1989-05-10

1993-07-27

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, A61K 3702, C07K 512

Patent

active

052310825

ABSTRACT:
The invention discloses a cyclic pentapeptide that inhibits metastasis of malignant cells.

REFERENCES:
patent: 4760066 (1988-07-01), Busse et al.
patent: 4870160 (1989-09-01), Charonis et al.
L. Furcht, et al. "Peptide Fragments of Fibronectin and Laminin: Role in Cell Adhesion and Inhibition of Experimental Tumor Metastasis", Development Oncology 41:43 (1986).
L. T. Furcht, et al. "Peptide Fragments of Laminin and Fibronectin Promote Migration (Haptotaxis and chemotaxis) of Metastatic Cells", CIBA Foundation Symposium 108:130 (1984).
J. Graf, et al. "Identification of an Amino Acid Sequence in Laminin Mediating Cell Attachment, Chemotaxis, and Receptor Binding", Cell 48:989 (1987).
Yukihide Iwamoto, et al. "YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation", Science 238, 1132-1134 (1987).
Makoto Sasaki, et al. "Sequence of the cDNA encoding the Laminin B1 Chain Reveals a Multidomain Protein Containing Cysteine-rich Repeats", Proc. Natl. Acad. Sci., USA 84:935 (1987).
Jeannette Graf, et al. "A Pentapeptide from the Laminin B1 Chain Mediates Cell Adhesion and Binds the 67000 Laminin Receptor", Biochemistry 26:6896 (1987).
Zubay, Biochemistry, Second Edition, 1983, pp. 36 and 37.
Stryer, Biochemistry, Third Edition, 1988, pp. 16 and 17,

Affiliated with

Also associated with

Rating

Cyclic peptide with anti-metastasis activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic peptide with anti-metastasis activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic peptide with anti-metastasis activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2342332