Cyclic peptide LHRH antagonists

Details Cyclic peptide LHRH antagonists Cyclic peptide LHRH antagonists

1994-03-09

1996-04-16

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

530317, 530328, C07K 1459, C07K 764

Patent

active

055083838

ABSTRACT:
A class of cyclic peptides are effective inhibitors of LHRH and are useful in the treatment of disease conditions which are mediated by sex hormones including prostate cancer, endometriosis, uterine fibroids, and precocious puberty.

REFERENCES:
patent: 5110904 (1992-05-01), Haviv et al.
patent: 5300492 (1994-04-01), Haviv et al.
J. Rivier, et al., Proceedings of the Ninth American Peptide Symposium Pierce Chemical Co., Rockford, IL 541-544, 1985.
R. M. Freidinger, et al., Proceedings of the Ninth American Peptide Symposium, Pierce Chemical Co., Rockford, IL 549-552, 1985.
J. Rivier, et al., J. Med. Chem. 31(3): 677-682 (1988).
A. S. Dutta, et al., Biochem. and Biophys. Res. Comm. 159(3): 1114-1120 (1989).
J. Rivier, et al., Proceedings of the 11th American Peptide Symposium 33-37 (1990).
R. S. Struthers, Proteins: Structure, Function, and Genetics, 8:295-304 (1990).
J. Rizo, et al., J. Am. Chem. Soc. 114(8):2852-2859 (1992).
J. Rivier, et al., Contraception 46:109-112 (1992).
R. J. Bienstock, et al., J. Med. Chem. 36:3265-3273 (1993).
A. S. Dutta, et al., Bioorganic and Med. Chem. Letters 3(5):943-948 (1993).

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