Cyclic peptide inhibitors of .beta..sub.1 and .beta..sub.2 integ

Details Cyclic peptide inhibitors of .beta..sub.1 and .beta..sub.2 integ Cyclic peptide inhibitors of .beta..sub.1 and .beta..sub.2 integ

1996-10-28

1998-10-13

Achutamurthy, Ponnathapura

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530318, 530328, 530329, 530330, 514 11, 514 16, 514 17, 514 18, A61K 3812, C07K 500, C07K 700

Patent

active

058213295

ABSTRACT:
The present invention describes cyclic peptide compounds which modulate integrin mediated adhesion. These compounds can inhibit both .beta..sub.1 and .beta..sub.2 mediated adhesion. The invention further relates to therapeutic uses for these compounds in the treatment of adhesion related pathologies.

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