Cyclic peptide CXCR4 antagonists

Details Cyclic peptide CXCR4 antagonists Cyclic peptide CXCR4 antagonists

2011-04-05

2011-04-05

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reissue Patent

active

RE042274

ABSTRACT:
Provided are lactam-cyclized peptide CXCR4 antagonists useful in the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis, and HIV infection.

REFERENCES:
patent: 2004 196769 (2004-07-01), None
patent: WO 2007/096662 (2007-08-01), None
Tamamura et al. (“Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides,” Current HIV Research, 2005, 3, 289-301).
Grande, et al., “Small Molecules Anti-HIV Therapeutics Targeting CXCR4,”Curr. Pharm. Design14:385-404 (2008).
Tamamura et al., “Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-Scaffolds Towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis,”Curr. Med. Chem.14:93-102 (2007).
Tamamura, et al., “Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides,”Curr. HIV Research3:289-301 (2005).
Ueda, et al., “Structure-Activity Relationships of Cyclic Peptide-Based Chemokine Receptor CXCR4 Antagonists: Disclosing the Importance of Side-Chain and Backbone Functionalities,”J. Med. Chem.50:192-198 (2007).

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