Cyclic peptide compounds

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

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Details

C530S328000, C514S011400

Reexamination Certificate

active

07872097

ABSTRACT:
The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

REFERENCES:
patent: 6927208 (2005-08-01), Wenger et al.
patent: WO 00/01715 (2000-01-01), None
patent: WO 02/32447 (2002-04-01), None
patent: WO 2005/021028 (2005-03-01), None
patent: WO 2005/032576 (2005-04-01), None
patent: WO 2006/038088 (2006-04-01), None
patent: WO 2006/039668 (2006-04-01), None
patent: WO 2006/054801 (2006-05-01), None
Soo Y. Ko, “Solid-Phase Total Synthesis of Cyclosporine Analogues”, Helvetica Chimica Ada, vol. 80, (1997), pp. 695-705.
Marian E. Major, et al., “Hepatitis C Viruses”, Virology 4thEdition, pp. 1127-1161, (2001).
Qui-Lim Choo et al., “Isolation of a cDNA Clone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome”, Science, vol. 244, pp. 359-362, (1989).
Markus Thall et al., “Functional Association of Cyclophilin A with HIV-1 Virions”, Nature, vol. 372, pp. 363-365, (1994).
K Inoue et al., “Antiviral Effect of Cyclosporin A on HCV Propagation”, NIH, Jun. 1989, 6thInternational Symposium on Hepatitis C and Related Virus.
Marina Berenguer et al., “HCV-Related Fibrosis Progression Following Liver Transplantation: Increase in Recent Years”, Journal of Hepatology, vol. 32, (2000), pp. 673-684.
Koichi Watashi et al., “Cyclosporin A Suppresses Replication of Hepatitis C Virus Genome in Cultured Hepatocytes”, J. Hepatology, vol. 38, No. 5, pp. 1282-1288 (2003).
Mina Nakagawa et al., “Specific Inhibition of Hepatitis C Virus Replication by Cyclosporin A”, Biochemical and Biophysical Research, vol. 313, No. 1, pp. 42-47 (2004).
Kazutoshi Sakamoto et al., “Taxonomy of the Producing Organism, Fermentation, Isolation, Physico-Chemical Properties and Biological Activities”, The Journal of Antibiotics, vol. 46, No. 12, pp. 1788-1798 (1993).
Office Action dated Mar. 10, 2010, in corresponding Israeli Application No. 190286, Examiner A. Fleider.
Office Action dated May 27, 2010, in corresponding Russian Application No. 2008116674, Examiner M. E. Gorbatovskaya.
Official Action in corresponding Russian Application No. 2008116674, apparent mailing date: Sep. 13, 2010.

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