Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1998-08-04
2000-03-28
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
514 7, 530345, 558152, A61K 3812, C07F 932, C07K 756
Patent
active
060433418
ABSTRACT:
The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs.
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patent: 5359115 (1994-10-01), Campbell et al.
patent: 5646111 (1997-07-01), Borromeo et al.
patent: 5786325 (1998-07-01), Borromeo et al.
J. Med. Chem., Balkovec, et al. (1992) vol. 35, 194-198.
Grutsch, Jr. John Leo
Hansen Marvin Martin
Harkness Allen Robert
Udodong Uko Effiong
Verral, II Daniel Edward
Eli Lilly & Co.
Russel Jeffrey E.
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