Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-12-20
1995-03-14
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514213, 514217, 514278, 514409, 514416, A61K 3147
Patent
active
053977890
ABSTRACT:
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
REFERENCES:
patent: 3044930 (1962-07-01), Goodhue et al.
patent: 3796715 (1974-03-01), Leimgruber et al.
patent: 3947451 (1978-09-01), Josson et al.
patent: 4117144 (1978-09-01), Jonsson et al.
patent: 4123543 (1978-10-01), Josson et al.
patent: 5025032 (1991-06-01), Carney et al.
Baggiolin et al, Chemical Abstracts, vol. 111, No. 25, Abstract 230,179e, p. 565, Dec. 18, 1989.
Dinarello et al, Chemical Abstracts, vol. 105, No. 21, Abstract 189,195t, p. 571, Nov. 24, 1986.
Seeger et al, Chem. Ber., vol. 103, 1970, pp. 1674-1691.
Thomae, Chemical Abstracts, vol. 74, 1971, Column 141.572c.
Kobor, Chemical Abstracts, vol. 77, 1972, Column 151.841r.
Jonsson et al, Chemical Abstracts, vol. 78, 1973, Column 159.460g.
Floyd, Role of oxygen free radicals in carcinogenesis and brain ischemia, FASEB Journal, vol. 4, pp. 2587-2599 (1990).
Bolli et al, Use of Spin Traps in Intact Animals Undergoing Myocardial Ischemia/Reperfusion: A New Approach to Assessing the Role of Oxygen Radicals in Myocardial "Stunning", Free Rad. Res. Comms., vol. 9 No. 3-6, pp. 169-180, 1990.
Oliver et al, Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain, Proc. Natl. Acad. Sci. USA vol. 87, pp. 5144-5147 Jul. 1990, Neurobiology.
Phillis, Protection from Cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-a-phenylnitrone (PBN) Neuroscience Letters, 116 (1990) 315-319.
Patent Abstracts of Japan vol. 12, No. 283 (C-518) (3130) 3 Aug. 1988 & JP-A-63 063 851.
Interleukin-1 and Interleukin-1 Antagonism, Blood, vol. 77, No. 8 (Apr. 15), 1991: pp. 1627-1652, Charles A. Dinerallo
An Unanesthetized-Gerbil Model of Cerebral Ischemia-induced Behavioral Changes, Journal of Pharmacological Methods 14, 137-146 (1985) Chandler, et al.
A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines, J. Org. Chem. 1991, 56, 6034-6038, Larsen et al.
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-a-phenylnitrone, Proc. Natl. Acad. Sci. USA vol. 88, pp. 3633-3636, May 1991 Neurobiology, Carney et al.
Murahashi et al, Tungstate-Catalyzed of Secondary Amines to Nitrones, a-Substitution of Secondary Amines via Nitrones; J. Org. Chem. 1990, 55, 1736-1744.
Bernotas Ronald C.
Carr Albert A.
Ku George
Thomas Craig E.
Davis Zinna N.
Dixon J. Michael
Ivy C. Warren
Merrell Dow Pharmaceuticals Inc.
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