Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-02-03
1996-05-28
Parr, Margaret
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 9, 514 2, 530317, 930270, A61K 3812, C07K 764
Patent
active
055211569
ABSTRACT:
Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.
REFERENCES:
patent: 4102877 (1978-07-01), Nutt
McKnight, et al., Brit. J. of Pharm, Proceedings Supplement 90:266P (Mar. 1987).
Suman-Chauhan, et al., Brit. J. of Pharm. Proceedings Supplement 95:747p (Dec. 1988).
Howarth, et al., British J. of Pharm. Proceedings Supplement 96:360P (Mar. 1989).
Rovero, et al., Peptides 10:593-595 (1989).
Hagiwara, D. et al., Studies on Neurokinin Antagonists 1. The Design of Novel Tripeptides Possessing the Glutaminyl-D-tryptophylphenylalanine Sequence as Substance P Antagonists, J. Med. Chem. 1992, 35, 2015-2025.
Hagiwara, D., et al., Studies on Neurokinin Antagonists. 2. Design and Structure-Activity Relationships of Novel Tripeptide Substance P Antagonists, N.sup..alpha. -[N.sup..alpha. -N.sup..alpha. -Acetyl-L-threonyl)-N.sup.1 -formyl-D-tryptophyl]-N-methyl-N-(phenyl-mehtyl)-L-phenylalaninamide and its Related Compounds.
Ichinose, M., et al, Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist, The Lancet, vol. 340, Nov. 21, 1992.
Barnes, P. J., et al., TIPS Reviews, May 1990, vol. 11, Modulation of neurogenic inflammation: novel approaches to inflammatory disease.
Sasaki, et al., "Solid Phase Synthesis of Peptides Containing the CH.sub.2 NH Peptide Bond Isostere" Peptides, vol. 8, pp. 119-121 (1987).
McKnight, A. T., et al. Regulatory Peptides 22 (1-2):126 (Jul. 1988).
Fletcher, et al., Brit. J. Pharm, Proceedings Supplement 91:360P (Jun. 1987).
McElroy et al, J. Med. Chem., vol. 35, pp. 2582-2591, (1992).
Harbeson, Peptides, Proceedings of the 11th Am. Pept. Symp., pp. 180-181, (Jul. 9-14, 1989).
Harbeson, Peptides, Proceedings of the 12th Am. Pept. Symp., (Jun. 16-21, 1991), pp. 124-125.
Maggi, Br. J. Pharmacol., vol. 108, pp. 588-592, (1990).
Buck Stephen H.
Harbeson Scott L.
Kudlacz Elizabeth M.
Owen Thomas J.
Boudreaux William R.
Merrell Pharmaceuticals Inc.
Parr Margaret
Wessendorf T. D.
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