Cyclic motilin receptor antagonists

Details Cyclic motilin receptor antagonists Cyclic motilin receptor antagonists

2006-03-28

2006-03-28

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S009100, C514S002600, C530S317000, C530S300000

Reexamination Certificate

active

07018981

ABSTRACT:
The present invention aims to provide cyclic peptide derivatives having motilin receptor antagonist activity and are useful as pharmaceuticals. The present invention provides compounds of general formula (1):wherein R1represents an optionally substituted phenyl group or the like; R2represents an amino group or the like; R3to R6represent a hydrogen atom, a methyl group or the like; R7represents a hydrogen atom or the like; V to Z represent a carbonyl group or a methylene group; m represents an integer of 0–2; and n represents an integer of 0–3; or a hydrate or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5972939 (1999-10-01), Chen et al.
patent: 6384031 (2002-05-01), Chen et al.
patent: 6586630 (2003-07-01), Matsuoka et al.
patent: 2004/0092478 (2004-05-01), Rothermel et al.
patent: 1 006 122 (2000-06-01), None
patent: 7-138284 (1995-05-01), None
patent: 2000-44595 (2000-02-01), None
patent: WO-00/17231 (2000-03-01), None
patent: WO-00/44770 (2000-08-01), None
patent: WO-02/08248 (2002-01-01), None
Takanashi H et al “GM-109: A Novel, Selective Motilin Receptor Antagonist in the Smooth Muscle of the Rabbit Small Intesting” Journal o fPharmacology and Expreimental Therapeutics, American Society for Pharmacology and, US, vol. 273, no. 2, (1995), pp:624-628.
Haramura Masayuki et al “Design and synthesis of N-Terminal cyclic motilin partial peptides: A novel pure motilin antagonist” Chemical and Pharmaceutical Bulletin (Tokyo), vol. 49, No. 1, (Jan. 2001) pp: 40-43.
Kazuhiro Momose et al. “Anxiolytic Effect of Motilin and Reversal with GM-109, a Motilin Antagonist. in Mice”Peptieds19(10) 1739-1742, (1998).
Takio Kitazawa et al. “Functional Characterization of Neural and Smooth Muscle Motilin Receptors in the Chicken Proventriculus and Ileum”Regulatory Peptieds71:87-95. (1997).
Shin Fukudo et al. “Colonic Motility. Autonomic Function, and Gastrointestinal Hormones under Psychological Stress on Irritable Bowel Syndrome”Tohoku J. Exp. Med.151: 373-385 (1987).
D M Preston et al. “Positive Correlation between Symptoms and Circulation Motilin. Pancreatic Polypeptide and Gastrin Concentrations in Functional Bowel Disorders”Gut26:1059-1064 (1985).
William L Hasler et al. “Erythromycin Contracts Rabbit Colon Myocytes via Occupation of Motilin Receptors”The American Physiological Society:G50-G55 (1992).

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