Cyclic malonamides as inhibitors of A-β protein...

Details Cyclic malonamides as inhibitors of A-β protein... Cyclic malonamides as inhibitors of A-β protein...

2006-05-30

2006-05-30

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S211040, C514S211050, C514S211070

Reexamination Certificate

active

07053081

ABSTRACT:
This invention relates to novel cyclic malonamides having the formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

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