Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2010-06-15
2011-11-08
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
08053432
ABSTRACT:
A compound of formula (I): in which X represents O or CH2; R3and R4each independently represent hydrogen or C1-6alkyl; p represent 0 or 1; and R represents a five- or six-membered saturated or unsaturated ring selected from: formula (II), (III) and (IV); or R represents a five- or six-membered oxo-substituted unsaturated ring selected from: (V) and (VI); wherein R1and R2together represent an oxo group, or R1and R2each represent hydrogen, methoxy or ethoxy, or R1and R2together with the interjacent carbon atom represent a 1,3-dioxolane or 1,3-dioxane ring, attached via the 2 position and optionally bearing one or more methyl or ethyl groups; or a salt thereof, is suitable for the treatment of anxiety and depression.
REFERENCES:
patent: 4241071 (1980-12-01), Martin et al.
patent: 5476867 (1995-12-01), Boyd et al.
patent: 5707988 (1998-01-01), Boyd et al.
patent: 05-255250 (1993-10-01), None
patent: WO 90/14342 (1990-11-01), None
patent: WO 95/17385 (1995-06-01), None
Murahashi et al;Tetrahedron Letters,vol. 26, No. 38; pp. 4633-4636 (1985).
Science,vol. 286; pp. 531-537 (1999).
Cancer and metastasis Reviews,vol. 17, No. 1; pp. 91-106 (1998).
Ali, S.A., et al; “Mercury(II) oxide Oxidation of 2-Substituted-N-hydroxypiperidine: A Solution to the Regiochemical Problem”;Tetrahedron Letters,vol. 34, No. 33, pp. 5325-5326 (1993).
Ali, S.A., et al; “Regiochemistry of Mercury(II) oxide Oxidation of UnsymmetricalN,N-Disubstituted Hydroxylamines”;Tetrahedron,vol. 52, No. 47, pp. 14917-14928 (1996).
Ali, S.A., et al; “Synthesis and Cycloaddition of 6-Substituted 3,4,5,6-Tetrahydropyridine 1-Oxides”;J. Chem. Research;Synop., vol. 2, pp. 54-55 (1994).
Banerji, A., et al; “Cycloaddition of C,N-Diarylnitrones to 2-Butenolide: Synthesis of 2,3,6,6a-Tetrahydrofuro[3,4-d]lisoxazol-4(3aH)-one”;Tetrahedron,vol. 48, No. 16, pp. 3335-3344 (1992) XP-001026252.
DeMarch, P., et al; “Asymmetric Induction in the Cycloaddition of a Maskedp-Benzoquinone to Cyclic Nitrones”;J. Org. Chem.;vol. 62, pp. 7781-7787 (1997) XP-002296430.
DeMarch, P., et al; “Efficient Masking ofp-Benzoquinone in Nitrone Cycloaddition Chemistry”;Tetrahedron Letters; vol. 36, No. 47, pp. 8665-8668 (1995).
Elsworth, J.F., et al; “Nitrones. Part IX. The Synthesis and Reactions of 2,3-Dihydro-1,4-oxazine 4-Oxide, a Heterocyclic Nitrone”;Journal of the Chemical Society; Section C: Organic Chemistry, No. 19, pp. 2423-2427 (1968) XP-001027088.
Kato, T., et al; “Reaction of Pyridine and Quinoline N-Oxides with Phenylmagnesium Bromide”;Y. Org. Chem.; vol. 30, No. 3, pp. 910-913 (1965).
Thesing, J., et al; “Cyclische Nitrone I: Dimeres 2,3,4,5-Tetrahydro-pyridin-N-oxyd”;Chem. Ber.,vol. 89, pp. 2159-2167 (1956).
Annis Michael
Parsons Phillip
Rosini Sergio
Trasciatti Silvia
Anderson Rebecca
BTG International Limited
Nixon & Vanderhye
LandOfFree
Cyclic hydroxylamine as psychoactive compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclic hydroxylamine as psychoactive compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic hydroxylamine as psychoactive compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4265716