Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-06-01
2010-11-30
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S173000
Reexamination Certificate
active
07842689
ABSTRACT:
A compound of formula (II):in which—R3and R4each independently represent hydrogen or C1-6alkyl; p represent 0 or 1; andR represents a five- or six-membered saturated or unsaturated ring selected from:R represents a five- or six-membered substituted or unsubstituted unsaturated ring selected from:wherein R1and R2together represent an oxo group, or R1and R2each represent hydrogen, methoxy or ethoxy, or R1and R2together with the interjacent carbon atom represent a 1,3-dioxolane or 1,3-dioxane ring, attached via the 2 position and optionally bearing one or more methyl or ethyl groups; or a salt thereof, which is suitable for the treatment of anxiety and depression.
REFERENCES:
patent: 5476867 (1995-12-01), Boyd et al.
patent: 5707988 (1998-01-01), Boyd et al.
patent: 05-255250 (1993-10-01), None
patent: WO 90/14342 (1990-11-01), None
patent: WO 95/17385 (1995-06-01), None
Science (1999), vol. 286, 531-537.
Cancer and Metastasis Reviews (1998), 17(1), 91-106.
Murahashi et al., Tetrahedron Letters, vol. 26, No. 38, pp. 4633-4636, 1985.
Ali, S.A., et al; “Mercury(II) oxide Oxidation of 2-Substituted-N-hydroxypiperidine: A Solution to the Regiochemical Problem”;Tetrahedron Letters, vol. 34, No. 33, pp. 5325-5326 (1993).
Ali, S.A., et al; “Regiochemistry of Mercury(II) oxide Oxidation of UnsymmetricalN,N-Disubstituted Hydroxylamines”;Tetrahedron, vol. 52, No. 47, pp. 14917-14928 (1996).
Ali, S.A., et al; “Synthesis and Cycloaddition of 6-Substituted 3,4,5,6-Tetrahydropyridine 1-Oxides”;J. Chem. Research; Synop., vol. 2, pp. 54-55 (1994).
Banerji, A., et al; “Cycloaddition of C,N-Diarylnitrones to 2-Butenolide: Synthesis of 2,3,6,6a-Tetrahydrofuro[3,4-d]isoxazo1-4(3aH)-one”;Tetrahedron, vol. 48, No. 16, pp. 3335-3344 (1992) XP-001026252.
DeMarch, P., et al; “Asymmetric Induction in the Cycloaddition of a Maskedp-Benzoquinone to Cyclic Nitrones”;J. Org. Chem.; vol. 62, pp. 7781-7787 (1997) XP-002296430.
DeMarch, P., et al; “Efficient Masking ofp-Benzoquinone in Nitrone Cycloaddition Chemistry”;Tetrahedron Letters; vol. 36, No. 47, pp. 8665-8668 (1995).
Elsworth, J.F., et al; “Nitrones. Part IX. The Synthesis and Reactions of 2,3-Dihydro-1,4-oxazine 4-Oxide, a Heterocyclic Nitrone”;Journal of the Chemical Society; Section C: Organic Chemistry, No. 19, pp. 2423-2427 (1968) XP-001027088.
Kato, T., et al; “Reaction of Pyridine and Quinoline N-Oxides with Phenylmagnesium Bromide”;Y. Org. Chem.; vol. 30, No. 3, pp. 910-913 (1965).
Thesing, J., et al; “Cyclische Nitrone I: Dimeres 2,3,4,5-Tetrahydro-pyridin-N-oxyd”;Chem. Ber., vol. 89, pp. 2159-2167 (1956).
Annis Michael
Parsons Phillip
Rosini Sergio
Trasciatti Silvia
Anderson Rebecca L
BTG International Limited
Nixon & Vanderhye
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