Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-02-20
1993-03-23
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546333, 564460, 540107, 514357, 514172, C07D21338, C07D31350, A61K 3158, A61K 3144
Patent
active
051965429
ABSTRACT:
Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.
REFERENCES:
patent: 3284475 (1966-11-01), Klimstra
patent: 3370070 (1968-02-01), Klimstra et al.
patent: 4239780 (1980-12-01), Wallach
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Blackwell, G. J., et al., "Phospholipase A.sub.2 Activity of Guinea-Pig Isolated Perfused Lungs: Stimulation, and Inhibition by Anti-Inflammatory Steroids", British J. Pharmacy, 62, pp. 79-89 (1978).
Wallach, D. P. and Brown, V. J. R., "Studies on the Arachidonic Acid Cascade-I", Bioch. Pharmacol., 30, pp. 1315-1324 (1981).
Doctoral Thesis, L. J. Griggs, "Part I. Synthetic Approaches to 6- and 16-Thiaestrone. Part II. Estrone with a Diazacholesterol Side Chain," University of Michigan (1965).
Klimstra, P. D., et al., "Hypocholesterolemic Agents. VI. A- and B-Ring-Modified Azacholesterols", J. Med. Chem., 9, pp. 323-326 (1966).
Bundy Gordon L.
Johnson Roy A.
Morton Douglas R.
Wallach, deceased Donald P.
Youngdale Gilbert A.
Bond Robert T.
The Upjohn Company
Wootton Thomas A.
Wright Debbie K.
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