Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Patent
1994-05-20
1997-04-15
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
552554, C07J 4100
Patent
active
056211236
ABSTRACT:
Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.
REFERENCES:
patent: 3084156 (1963-04-01), Counsell et al.
patent: 3107255 (1963-10-01), Counsell et al.
patent: 3284474 (1966-11-01), Klimstra
patent: 3284475 (1966-11-01), Klimstra
patent: 3326758 (1967-06-01), Irmscher et al.
patent: 3370070 (1968-02-01), Klimstra
patent: 3639598 (1972-02-01), Klimstra
patent: 4239780 (1980-12-01), Wallach
patent: 4330539 (1982-05-01), Sleigh et al.
patent: 5075434 (1991-12-01), Youngdale
W. Vogt, Advances in Prostaglandins and Thromboxane Research, 3:89-95 (1978).
P.C. Isakson et al, Advances in Prostaglandin and Thromboxane Research, 3-113-120 (1978).
N.A. Plummer et al, Journal of Investigative Dermatology, 68:246 (1977).
B.B. Vargaftig, J. Pharm. Pharmacol., 29:222-228 (1977).
R.J. Flower et al, Nature, 278:456-459 (1979).
L. Kaplan et al, Proc. Natl. Acad. Sci., 75:2955-2988 (1978).
E. Vallee et al, J. Pharm. Pharmacol., 31:588-592 (1974).
M. Roberts et al., J. of Biol. Chem., 252:2405-2411 (1977).
G.J. Blackwell et al, British J. Pharmacy, 62:79-89 (1978).
D.P. Wallach et al, Bioch. Pharmacol., 30:1315-1324 (1981).
L.J. Griggs, "Part I. Synthetic Approaches to 5- and 16-Thiaestrone. Part II. Estrone With a Diazacholesterol Side Chain", University of Michigan (1965).
P.D. Klimstra et al., J. Med. Chem., 9:323-326 (1966).
Klimstra et al. Hypocholesterolenic Agents VI, May, 1966 pp. 323-325.
Grant and Hackh's Chemical Dictionary (New York, McGraw-Hill, 1987) p. 14.
Vogt, W., "Role of Phospholipase A.sub.2 in Prostaglandin Formation", Advances in Prostaglandins and Thromboxane Research, 3, p. 89 (1978).
Isakson, P.C. et al., "Lipases and Prostaglandin Biosynthesis", Advances in Prostaglandin and Thromboxane Research, 3, p. 113, (1978).
Plummer, N.A., et al., "Activation of the Arachidonate Cascade in Human Skin Inflamed by Irradiation with UVC and the Effects of Indomethacin", abstracted in Journal of Investigative Dermatology, 68, p. 246 (1977).
Vargaftig, B.B., "Carrageenan and thrombin trigger prostaglandin synthetase-independent aggregation of rabbit platelets: inhibition by phospholipase A.sub.2 inhibitors", J. Pharm. Pharmacol., 29, pp. 222-228 (1977).
Flower, R.J. and Blackwell, G.J., "Anti-inflammatory steroids induce biosynthesis of a phospholipase A.sub.2 inhibitor which prevents prostaglandin generation", Nature, 278, pp. 456-459 (1979).
Kaplan, K.L., et al., "Low concentrations of indomethacin inhibit phospholipase A.sub.2 of rabbit polymorphonuclear leukocytes", Proc. Natl. Acad. Sci., 75, pp. 2955-2988 (1978).
Vallee, E., et al., "Anti-inflammatory and platelet anti-aggregant activity of phospholipase-A.sub.2 inhibitors", J. Pharm. Pharmacol., 31, pp. 588-592 (1974).
Roberts, M.F., et al., "Chemical Modification of the Histidine Residue in Phospholipase A.sub.2 ", J. of Biol. Chem., 252, pp. 2405-2411 (1977).
Blackwell, G.J., et al., "Phospholipase A.sub.2 Activity of Guinea-Pig Isolated Perfused Lungs: Stimulation, and Inhibition by Anti-Inflammatory Steroids", British J. Pharmacy, 62, pp. 79-89 (1978).
Wallach, D.P. and Brown, V.J.R., "Studies on the Arachidonic Acid Cascade-I", Bioch. Pharmacol., 30, pp. 1315-1324 (1981).
Doctoral thesis, L.J. Griggs, "Part I. Synthetic Approaches to 6- and 16-Thiaestrone. Part II. Estrone with a Diazacholesterol Side Chain," University of Michigan (1965).
Klimstra, P.D., et al., "Hypocholesterolemic Agents. VI. A- and B-Ring-Modified Azacholesterols", J. Med. Chem., 9, pp. 323-326 (1966).
Bundy Gordon L.
Johnson Roy A.
Morton Douglas R.
Wallach, deceased Donald P.
Wallach, legal representative Vera M.
Shah Mukund J.
Sripada Pavanaram K.
The Upjohn Company
Wootton Thomas A.
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