Cyclic hexapeptides having antibiotic activity

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

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Details

C530S329000, C514S011400, C514S017400

Reexamination Certificate

active

06884868

ABSTRACT:
This invention relates to new polypeptide compound represented by general formula (I), wherein R1, R2, R3, R4, R5and R6are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases includingPneumocystis cariniiinfection (e.g.Pneumocystis cariniipneumonia) in a human being or an animal.

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R. A. Zambias, et al., Biooraganic & Medicinal Chemistry Letters, vol. 5, No. 20, pps. 2357-2362, “Antifungal Lipopeptides: Structure-Activity Relationships of 3-Hydroxyglutamine-Modified Pneumocandin BO Derivatives”, Oct. 19, 1995.

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