Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-10-31
1980-11-25
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125S, A61K 3700, C07C10352
Patent
active
042358868
ABSTRACT:
Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synethesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method.
REFERENCES:
patent: 4140767 (1979-02-01), Veber et al.
patent: 4161521 (1979-07-01), Veber et al.
patent: 4162248 (1979-07-01), Strachan et al.
DerWent Abstract 26448b/14; of European Patent 1295 Apr. 4, 1979.
Freidinger Roger M.
Veber Daniel F.
Merck & Co. , Inc.
Phillips Delbert R.
Rose David L.
Westlake Harry E.
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