Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1990-12-17
1993-07-06
Bond, Robert T.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530315, 540455, 540460, C07D48714, A61K 3702
Patent
active
052255280
ABSTRACT:
Disclosed are cyclic hexapeptides of the formula: ##STR1## These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing the compounds of formula I and methods of preparing these compounds.
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Bock Mark G.
Freidinger Roger M.
Tung Roger D.
Veber Daniel F.
Williams Peter D.
Bond Robert T.
Caruso C. M.
Grassler Frank P.
Merck & Co. , Inc.
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