Cyclic GMP phosphodiesterase

Details Cyclic GMP phosphodiesterase Cyclic GMP phosphodiesterase

1997-12-09

1999-07-13

Huff, Sheela

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 435 6, 536 231, 536 235, 530350, C12N 1500

Patent

active

059225955

ABSTRACT:
The invention provides a human cyclic GMP phosphodiesterase (PDE9A) and polynucleotides which identify and encode PDE9A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE9A.

REFERENCES:
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Verghese, M.W. et al., "Regulation of Distinct Cyclic AMP-Specific Phosphodiesterase (Phosphodiesterase Type 4) Isozymes in Human Monocytic Cells", Mol. Pharmacol., 47: 1164-1171 (1995).
Angel, J.B. et al., "Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication", AIDS, 9: 1137-1144 (1995).
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Sasaki, H. et al., "Suppression of oro-facial movements by rolipram, a cAMP phosphodiesterase inhibitor, in rats chronically treated with haloperido", Eur. J. Pharmacol., 282: 71-76 (1995).
Banner, K.H. and C.P. Page, "Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma", Eur. Respir. J., 8: 996-1000 (1995).
Bang, Y.-J. et al., "Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP", Proc. Natl. Acad. Sci. USA, 91: 5330-5334 (1994).
Matousovic, K. et al., "Inhibitors of Cyclic Nucleotide Phosphodiesterase Isozymes Type-III and Type-IV Suppress Mitogenesis of Rat Mesangial Cells", J. Clin. Invest., 96: 401-410 (1995).
Joulain, C. et al., "Influence of polyunsaturated fatty acids on lipid metabolism in human blood mononuclear cells and early biochemical events associated with lymphocyte activation", J. Lipid Mediat. Cell Signal., 11: 63-79 (1995).
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Davis, R. and Y. Qiu, (Direct Submission), GenBank Sequence Database (Accession X55167, S70588, S70600, X55247), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 7897; GI 829179) Jun. 1993.
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Segel, I.H., Enzyme Kinetics, John Wiley and Sons, New York, NY, pp. 214-245 (1995).

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