Cyclic FR-900520 microbial biotransformation agent

Details Cyclic FR-900520 microbial biotransformation agent Cyclic FR-900520 microbial biotransformation agent

1992-09-28

1993-12-07

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435170, C12P 1718, C12P 104

Patent

active

052682811

ABSTRACT:
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6968) ATCC No. 55279. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.

REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4081531 (1978-03-01), Arai
patent: 4242453 (1980-12-01), Umezawa et al.
patent: 4264607 (1981-04-01), Dewey et al.
patent: 4894344 (1990-01-01), Sugiyama et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 5149701 (1992-09-01), Shafiee et al.
Hatanaka et al., The Journal of Antibiotics, XLI (11), 1592-1601, (Nov. 1988).
Hatanaka et al., The Journal of Antibiotics, XLII (4), 620-622, (Apr. 1989).
Arai et al., J. Antibiotics, Ser. A. 15, (1962) pp. 231-232.

Affiliated with

Also associated with

Rating

Cyclic FR-900520 microbial biotransformation agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic FR-900520 microbial biotransformation agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic FR-900520 microbial biotransformation agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2015176