Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-09-28
1994-02-01
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435170, C12P 1718, C12P 104
Patent
active
052831833
ABSTRACT:
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6971) ATCC No. 55282. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
REFERENCES:
patent: 3244592 (1966-04-01), Arai
patent: 4081531 (1978-03-01), Arai
patent: 4242453 (1980-12-01), Umezawa et al.
patent: 4264607 (1981-04-01), Dewey et al.
patent: 4894344 (1990-01-01), Sugiyama et al.
patent: 5149701 (1992-09-01), Shafiee et al.
Hatanaka et al., The Journal of Antibiotics, XLI (11), 1592-1601 (Nov. 1988).
Hatanaka et al., The Journal of Antibiotics, XLII (4), 620-622, (Apr. 1989).
Arai et al., J. Antibiotics, Ser. A. 15, (1962) pp. 231-232.
Chen Shieh-Shung T.
Garrity George M.
Caruso Charles M.
Merck & Co. , Inc.
North Robert J.
Osoteo Maria
Quagliato Carol S.
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