Cyclic double hemiacetals of enediol compounds and compositions

Details Cyclic double hemiacetals of enediol compounds and compositions Cyclic double hemiacetals of enediol compounds and compositions

1979-04-06

1980-12-09

Randolph, John D.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

424279, 424285, 2603406, C07D49304, C07D31912, A61K 31335, A61K 31365

Patent

active

042385008

ABSTRACT:
Novel chemical compounds of the general formulae: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein R.sub.3 through R.sub.10 are hydrogen, alkyl, or aryl, wherein R.sub.5 and R.sub.6 together may form .dbd.0, and wherein X is hydroxy. The compounds are prepared by mixing specified amounts of a dialdehyde, .alpha.-keto-aldehyde, or diketone, such as methylglyoxal or a related compound, and an enediol, such as L-ascorbic acid or a compound that can be converted into an enediol, such as an acyloin, and allowing same to react under a nitrogen atmosphere in the presence of a non-interfering solvent.
Compositions containing these novel compounds exhibit cytostatic, hypotensive and analgesic properties and are useful in the treatment of cancer in animals and humans.

REFERENCES:
patent: 3048598 (1962-08-01), Croxall et al.
patent: 3555006 (1967-06-01), Storfer
patent: 3847948 (1974-11-01), Yamamoto et al.
patent: 4096321 (1978-06-01), Weigele et al.
Chem. Abst. 2261CS., vol. 86, 1977.
Freireich et al. Cancer Chemotherapy Report, No. 16, Feb. 1962, pp. 183-186.
Mihich, Cancer Research, vol. 23, Sep. 1963, pp. 1375-1389.
Alan Saito et al., Biochem. Biophys. Acta 103 (1965), pp. 174-179.

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