Cyclic dithiodiacetamides and compositions containing them

Details Cyclic dithiodiacetamides and compositions containing them Cyclic dithiodiacetamides and compositions containing them

1984-05-17

1987-02-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514228, 514255, 514316, 514422, 544 584, 544 85, 546189, 548523, A61K 31535, A61K 3154, C07D26530, C07D27912

Patent

active

046423060

ABSTRACT:
The present invention relates to cyclic dithiodiacetamides with action inhibiting the malformation or the destruction of the red blood corpuscles due to a genetic modification of the haemoglobin or to parasites, of formula: ##STR1## in which X is a direct bond, an atom of oxygen or of sulfur, a methylene group, an ethylene group or an N--R group, where R is an atom of hydrogen or a lower alkyl group, lower (hydroxy)alkyl group, lower alkanoyl group or a phenyl group; to their possible pharmaceutically acceptable salts; to a process for preparing them from a dithiodiacetate or a mercaptoacetate of lower alkyl by transamination and possible oxidation; and to pharmaceutical compositions containing them as active ingredients, useful for the treatment for example of drepanocytosis, or sickle cell anaemia, of malaria and of babebiosis.

REFERENCES:
Nishimura et al, Chemical Abstracts, vol. 62, (1965) 2750c.

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