Cyclic derivatives of alkyl dihydroxyalkylxanthenes

Details Cyclic derivatives of alkyl dihydroxyalkylxanthenes Cyclic derivatives of alkyl dihydroxyalkylxanthenes

1986-04-04

1987-12-15

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544273, 549455, 549563, C07D40506

Patent

active

047134550

ABSTRACT:
Compounds of the formula ##STR1## wherein one of the radicals R.sup.1, R.sup.2 or R.sup.3 denotes a straight-chain alkyl group having 4 to 8 C atoms and two vicinal hydroxyl groups in the .omega.,.omega.-1 or .omega.-1,.omega.-2 positions and the two other radicals represent straight-chain or branched alkyl groups having up to 12 C atoms in the position of R.sup.1 and R.sup.3 and up to 4 C atoms in the position of R.sup.2, the total of C atoms in these two alkyl substituents being a maximum of 14, are prepared by oxidation of the corresponding alkenylxanthines and by alkylation with compounds which introduce the dihydroxyalkyl radical or a precursor thereof. The dihydroxyalkyldialkylxanthines are suitable for the treatment of obstructive respiratory tract diseases.

REFERENCES:
patent: 4397779 (1983-08-01), Groman et al.
patent: 4451449 (1984-05-01), Goring
Avico, et al., "Chemical Abstracts", vol. 57, 1962, col. 16605a.
Franzone, et al., "Chemical Abstracts", vol. 96, 1982, col. 96:6482n.

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